Redheads and anesthesia

If this is the case, then -- through our genetic quirks -- redheads have inspired research that may one day lead to safer medicine. As a result, redheads tend to be particularly nervous about dental procedures and are twice as likely to avoid going to the dentist as people with other hair colors, according to new research published in The Journal of the American Dental Association. Elizabeth Warren nets endorsement of health care activist Ady Barkan. Grandfather charged in cruise ship death faces prosecutors in court. At any rate, redheads exhibit a number of intriguing features.
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References

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Redheads Have Greater Fear Of Dentists

Binkley encourages dentists to "pay more attention, evaluate everyone for dental anxiety, and ask them about previous experiences. Most redheads have a recessive version of the MC1R gene. It really is a disincentive to have the procedures. In , research revealed that people with red hair need 20 percent more general anesthesia than blonds and brunettes. Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor. However, this is where things get interesting.
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Redheads and Anesthesia | Surgi-Ready

According to the authors, unpleasant experiences at the dentist could make patients less likely to have regular dental care, which would in turn worsen any problems they may already have. Anesthetic potency MAC is independent of forebrain structures in the rat. The dental study involving test subjects found that about 25 percent of the non-redheads also had variants of the MC1R gene. As the doctor began threading the needle through my skin, I bit down hard to prevent myself from crying out in pain. This seems to strongly indicate that redheads process pain differently than other people, probably due to MCR1.
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Heureusement, Gradwohl et coll. CrossRef Google Scholar. The next phase of research is to determine whether people with red hair and those with variants of the MCR1 gene need higher doses of anesthesia for dental procedures. If this is the case, then -- through our genetic quirks -- redheads have inspired research that may one day lead to safer medicine. Eur J Pharmacol ; Consistent with these admittedly vague impressions, investigators in several exploratory studies have concluded that redheads differ from people with other hair colours in their sensitivity to volatile anesthetics, local anesthetics, and opioids.
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